Description
An orally bioavailable inhibitor of HIV-1 integrase (IC50 = 15 nM in a strand transfer assay); inhibits the spread of HIV-1IIIb infection in MT-4 cell culture (CIC95s = 19 and 31 nM in medium containing 10% heat-inactivated FBS or 50% normal human serum, respectively); is metabolized in the liver primarily by UGT1A1